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When ulcerative colitis causes a flare-up of gastrointestinal symptoms, people also may have the following: Inflammation of the joints (arthritis) Inflammation of the whites of the eyes (episcleritis) Inflamed skin nodules (erythema nodosum) When ulcerative colitis is not causing a flare-up of gastrointestinal symptoms, people still may have complications that occur entirely without relation to the bowel disease such as the following: Dusky purple skin sores that may contain pus (pyoderma gangrenosum) Inflammation of the spine Inflammation of the pelvic joints (sacroiliitis) Inflammation of the inside of the eye (uveitis) Although people with ulcerative colitis commonly have minor liver dysfunction, only about 1 to 3% have symptoms of liver disease, which vary from mild to severe

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